1217651-02-9 Usage
Description
Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.
Chemical Properties
Crystalline Solid
Check Digit Verification of cas no
The CAS Registry Mumber 1217651-02-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,6,5 and 1 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1217651-02:
(9*1)+(8*2)+(7*1)+(6*7)+(5*6)+(4*5)+(3*1)+(2*0)+(1*2)=129
129 % 10 = 9
So 1217651-02-9 is a valid CAS Registry Number.
1217651-02-9Relevant articles and documents
SULFONAMIDE INHIBITORS OF CARBONIC ANHYDRASE
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Page/Page column 19, (2010/12/29)
The present invention relates to new sulfonamide inhibitors of carbonic anhydrase activity, pharmaceutical compositions thereof, and methods of use thereof.
