1217669-36-7

Basic information

• Product Name: 5'-Des-O-methylhomoharringtonine-13C,d3
• Synonyms: 4'-Demethyl Homoharringtonine-13C,d3;5'-Des-O-methylhomoharringtonine-13C,d3;Cephalotaxine-13C,d3 4-Hydrogen (2R)-2-Hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)
• CAS NO: 1217669-36-7
• Molecular Formula: C28H37NO9
• Molecular Weight: 531.59468
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Isotope Labeled Compounds;Metabolites & Impurities;Pharmaceuticals;Isotope Labelled Compounds
• Mol File: 1217669-36-7.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5'-Des-O-methylhomoharringtonine-13C,d3(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-Des-O-methylhomoharringtonine-13C,d3(1217669-36-7)
• EPA Substance Registry System: 5'-Des-O-methylhomoharringtonine-13C,d3(1217669-36-7)

Safety Data

• Hazardous Substances Data: 1217669-36-7(Hazardous Substances Data)

Usage

Description

5'-Des-O-methylhomoharringtonine-13C,d3 is a labeled metabolite of Homoharringtonine, which is a cytotoxic component derived from the evergreen plant Cephalotaxus harringtonia. 5'-Des-O-methylhomoharringtonine-13C,d3 is characterized by the presence of stable isotopes, specifically carbon-13 (13C) and deuterium (D or 2H), which allow for its detection and tracking in various biological systems.

Uses

Used in Pharmaceutical Industry:
5'-Des-O-methylhomoharringtonine-13C,d3 is used as a research tool for studying the metabolism and pharmacokinetics of Homoharringtonine. The incorporation of stable isotopes enables researchers to trace the compound's distribution, absorption, and excretion in the body, providing valuable insights into its therapeutic potential and safety profile.
Used in Cancer Research:
In cancer research, 5'-Des-O-methylhomoharringtonine-13C,d3 serves as a labeled analog of the cytotoxic drug Homoharringtonine. It is used to investigate the mechanisms of action and potential applications in the treatment of various types of cancer. The stable isotopes allow for the detection and quantification of the compound in cellular and animal models, facilitating the evaluation of its efficacy and side effects.
Used in Drug Development:
5'-Des-O-methylhomoharringtonine-13C,d3 is utilized in the development of new drugs and therapies targeting cancer. The stable isotope labeling enables researchers to study the compound's interactions with biological targets, such as enzymes and receptors, and to optimize its structure for improved potency and selectivity. This information can be crucial in the design of more effective and safer anticancer agents.
Used in Drug Metabolism Studies:
5'-Des-O-methylhomoharringtonine-13C,d3 is employed in drug metabolism studies to understand how the body processes and eliminates Homoharringtonine. By tracking the labeled metabolite, researchers can identify and characterize the metabolic pathways involved, which can help in predicting potential drug-drug interactions and assessing the compound's overall safety and tolerability.
Used in Analytical Chemistry:
In analytical chemistry, 5'-Des-O-methylhomoharringtonine-13C,d3 can be used as an internal standard or reference material for the quantification of Homoharringtonine and its metabolites in biological samples. The stable isotope labeling provides a reliable and accurate means of correcting for sample preparation and instrumental variability, ensuring the precision and reliability of the analytical results.