ABT 737-d8 is a selective inhibitor of BCL-2, a protein that plays a crucial role in regulating cell survival and apoptosis. It is a yellow solid with potential applications in the field of cancer treatment.
1217686-68-4
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Basic information
- Product Name: ABT 737-d8
- Synonyms: ABT 737-d8;4-[4-[(4'-Chloro[1,1'-biphenyl]-2-yl)Methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(diMethylaMino)-1-[(phenylthio)Methyl]propyl]aMino]-3-nitrophenyl]sulfonyl]benzaMide-d8
- CAS NO:1217686-68-4
- Molecular Formula: C42H45ClN6O5S2
- Molecular Weight: 813.4269
- EINECS: N/A
- Product Categories: Chiral Reagents;Inhibitors;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Pharmaceuticals;Sulfur & Selenium Compounds
- Mol File: 1217686-68-4.mol
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Chemical Properties
- Melting Point: 148-150?C
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -20°C Freezer
- Solubility: DMSO
- CAS DataBase Reference: ABT 737-d8(CAS DataBase Reference)
- NIST Chemistry Reference: ABT 737-d8(1217686-68-4)
- EPA Substance Registry System: ABT 737-d8(1217686-68-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1217686-68-4(Hazardous Substances Data)
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1217686-68-4 Usage
Uses
Used in Pharmaceutical Industry:ABT 737-d8 is used as an anticancer agent for small cell lung cancer (SCLC). It has been shown to induce dramatic regressions in tumors derived from some SCLC cell lines, making it a promising candidate for targeted cancer therapy.
Used in Drug Development:
ABT 737-d8 is used as a research tool in the development of new drugs targeting BCL-2 proteins. Its selective inhibition of BCL-2 can help researchers understand the role of these proteins in cancer and other diseases, potentially leading to the discovery of novel therapeutic strategies.
Used in Chemical Research:
As a yellow solid with specific chemical properties, ABT 737-d8 can be used in chemical research to study the structure-activity relationship of BCL-2 inhibitors and to develop new compounds with improved potency and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1217686-68-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,7,6,8 and 6 respectively; the second part has 2 digits, 6 and 8 respectively.Calculate Digit Verification of CAS Registry Number 1217686-68:
(9*1)+(8*2)+(7*1)+(6*7)+(5*6)+(4*8)+(3*6)+(2*6)+(1*8)=174
174 % 10 = 4
So 1217686-68-4 is a valid CAS Registry Number.
1217686-68-4Upstream product
1217686-68-4Downstream Products
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ABT 737-d8
