1217795-44-2Relevant academic research and scientific papers
BF3-promoted synthesis of diarylhexahydrobenzo[f]isoquinoline
Chang, Meng-Yang,Lin, Chung-Han,Chen, Yeh-Long,Chang, Ching-Yao,Hsu, Ru-Ting
supporting information; experimental part, p. 1176 - 1179 (2010/05/18)
Chemical Equation Presented An easy and straightforward synthesis of 6,10b-diarylhexahydrobenzo[f]isoquinoline by the repeated treatment of boron trifluoride etherate (BF3·OEt2) is reported. The overall transformation from 4-arylpiperidin-3-one to benzo[f]isoqulnoline proceeds via ring contraction, chain elongation, and intramolecular electrophilic cyclization in moderate yields. It presents a novel rearrangement reaction catalyzed by boron trifluoride etherate and broadens the scope of application.
