1217833-76-5Relevant academic research and scientific papers
Bis-Cyclic Guanidines as a Novel Class of Compounds Potent against Clostridium difficile
Li, Chunhui,Teng, Peng,Peng, Zhong,Sang, Peng,Sun, Xingmin,Cai, Jianfeng
, p. 1414 - 1420 (2018)
Clostridium difficile infection (CDI) symptoms range from diarrhea to severe toxic megacolon and even death. Due to its rapid acquisition of resistance, C. difficile is listed as an urgent antibiotic-resistant threat, and has surpassed methicillin-resista
Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential
Teng, Peng,Nimmagadda, Alekhya,Su, Ma,Hong, Yuzhu,Shen, Ning,Li, Chunpu,Tsai, Ling-Yu,Cao, Jessica,Li, Qi,Cai, Jianfeng
, p. 11948 - 11951 (2017)
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistanc
