1217863-06-3

Basic information

• Product Name: 2-cyclohexen-1-one, 3-[(5-methyl-3-isoxazolyl)amino]-
• Synonyms: 2-cyclohexen-1-one, 3-[(5-methyl-3-isoxazolyl)amino]-;3-[(5-methylisoxazol-3-yl)amino]cyclohex-2-en-1-one;3-[(5-methyl-1,2-oxazol-3-yl)amino]cyclohex-2-en-1-one;3-((5-METHYLISOXAZOL-3-YL)AMINO)CYCLOHEX-2-ENONE
• CAS NO: 1217863-06-3
• Molecular Formula: C₁₀H₁₂N₂O₂
• Molecular Weight: 192.21448
• Mol File: 1217863-06-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-cyclohexen-1-one, 3-[(5-methyl-3-isoxazolyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyclohexen-1-one, 3-[(5-methyl-3-isoxazolyl)amino]-(1217863-06-3)
• EPA Substance Registry System: 2-cyclohexen-1-one, 3-[(5-methyl-3-isoxazolyl)amino]-(1217863-06-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1217863-06-3(Hazardous Substances Data)

Upstream product

• 1072-67-9 5-methylisoxazol-3-ylamine 
• 30182-67-3 1,3-Cyclohexanedione 

Relevant articles and documents

Enaminones 12. An explanation of anticonvulsant activity and toxicity per Linus Pauling's clathrate hypothesis

The x-ray crystal structure of 3-((5-methylisoxazol-3-yl)amino)-5- methylcyclohex-2-enone (12b) and 3-((5-methylisoxazolyl-3-yl)amino)-5,5- dimethylcyclohex-2-enone (12c) were determined and correlated to their anticonvulsant activity in mice and rats. A hypothesis for the toxicity of the analogs are advanced. In addition, a series of 5-methyl-N-(3-oxocyclohex-1-enyl) -isoxazole-3-carboxamides were synthesized and evaluated for anticonvulsant activity. These compounds were compared to the activity of the corresponding amino and aminomethyl enaminones. Additional investigation involved the synthesis and evaluation of a trifluoromethyl analog of the active isoxazole tert-butyl 4-(5-methisoxazol-3-yl-amino)-6-methyl-2-oxo-cyclohex-3-ene carboxylate (4f).