121787-07-3

Upstream product

• 186581-53-3 diazomethane 

Downstream Products

• 121719-95-7 (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-1-pentanol 
• 121719-95-7 (2'R,2R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-1-pentanol 
• 121719-93-5 (2'R,3S,4R)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentanol 
• 121719-93-5 (2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentanol 
• 121719-96-8 (2'R,2S,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxypentanoic acid 
• 146070-68-0 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (4S,5R)-4,5-dimethyl-5-((R)-1-methyl-2-oxo-ethyl)-[1,3]dioxolan-4-ylmethyl ester 
• 121719-94-6 (2'R,3R,4S)-5-<2'-methoxy-2'-(trifluoromethyl)phenylacetoxy>-2,3,4-trimethyl-3,4-methylenedioxy-2-pentene 

Relevant academic research and scientific papers

TOTAL SYNTHESIS OF OPTICALLY ACTIVE MONOCROTALINE, A CARCINOGENIC PYRROLIZIDINE ALKALOID HAVING AN 11-MEMBERED DILACTONE

Monocrotaline (1), a representative of carcinogenic pyrrolizidine alkaloids with an 11-membered dilactone has been synthesized in optically active form by virtue of regioselective coupling of (+)-retronecine (2) and the protected necic acid 3, the latter being synthesized enantioselectively from the meso-diester 4.