121805-97-8Relevant articles and documents
Alkylation of 2-acetylpyrrole and 1-alkyl-2-acetylpyrroles under solid/liquid phase-transfer conditions
Goldberg Yu.,Abele,Shymanska
, p. 557 - 562 (1991)
The alkylation of 2-acetylpyrrole with alkyl iodides in the benzene/solid KOH system in the presence of 18-crown-6 at room temperature gives the corresponding 1-alkyl derivatives in high yields. The phase-transfer catalysed alkylation of 1-alkyl-2-acetylpyrroles without solvent leads to side-chain di-C-alkylated products, i.e. ketones of the (1-alkyl-2-pyrrolyl)COCHR2 type in satisfactory yields.
N-(lower alkyl)-2-(3'ureidobenzyl)pyrrolidines
-
, (2008/06/13)
N-(lower alkyl)-2-(3'-ureidobenzyl)pyrrolidines and N-(lower alkyl)-2-(3'-ureidobenzyl)-5-(lower alkyl)pyrrolidines are useful for lowering intraocular pressure in mammals, for example, in the treatment of glaucoma.