121810-98-8

Basic information

• Product Name: N-methylpyrrole-2-carboxylic N,N-diphenylcarbamic anhydride
• CAS NO: 121810-98-8
• Molecular Weight: 320.348
• Mol File: 121810-98-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-methylpyrrole-2-carboxylic N,N-diphenylcarbamic anhydride(CAS DataBase Reference)
• NIST Chemistry Reference: N-methylpyrrole-2-carboxylic N,N-diphenylcarbamic anhydride(121810-98-8)
• EPA Substance Registry System: N-methylpyrrole-2-carboxylic N,N-diphenylcarbamic anhydride(121810-98-8)

Safety Data

• Hazardous Substances Data: 121810-98-8(Hazardous Substances Data)

Upstream product

• 6973-60-0 1-Methyl-2-pyrrolecarboxylic acid 
• 1228-96-2 1-[(diphenylamino)carbonyl]pyridinium chloride 

Relevant articles and documents

Topically Active Carbonic Anhydrase Inhibitors. 1. O-Acyl Derivatives of 6-Hydroxybenzothiazole-2-sulfonamide

A series of O-acyl derivatives of 6-hydroxybenzothiazole-2-sulfonamide (4, L-643,799) was prepared and the potential utility of each series member as a topically active inhibitor of ocular carbonic anhydrase was determined.In vitro studies showed these esters to be substrates for ocular esterases which liberate 4 during corneal translocation.The most interesting series member, 2-sulfamoyl-6-benzothiazolyl 2,2-dimethylpropionate (22, L-645,151), acting as a prodrug form of 4, was found to enhance delivery through the isolated albino rabbit cornea by 40-fold when compared to the parent phenol 4.Studies in rabbits revealed that 22 is a potent topically active ocular hypotensive carbonic anhydrase inhibitor.