121868-75-5

Upstream product

• 121868-68-6 3-<<2-<2,5-Bis(benzyloxy)-4-methylphenyl>-1-methylethyl>amino>-5,5-dimethyl-2-cyclohexen-1-on 
• 126-81-8 dimedone 
• 91125-85-8 1-(2,5-Dibenzyloxy-4-methyl-phenyl)-2-amino-propan 

Downstream Products

• 121868-82-4 2-<2-<(5,5-Dimethyl-3-oxo-1-cyclohexen-1-yl)amino>propyl>-5-methyl-1,4-benzochinon 

Relevant academic research and scientific papers

Investigations on the Formation of 6-Hydroxyindole in the Nenitzescu Reaction, II. - Cyclization of N-(Quinonylalkyl)enaminone Derivatives

The N-(quinonylethyl)enaminones 8a-d are synthesized from the phenylethylamines 5a,b.Quinones 8a,c,d are cyclized to the spiro compounds 9a,c,d.N-(Quinonylmethyl)enaminones 19a,b are obtained from aldehyde 12 via 13, 14, 15, and 16.Enaminone 19a cyclizes spontaneously to spiro compound 20.Ring closure of 19b yields isoquinolinium salts 21a,b.N-(Quinonylpropyl)enaminone 25 is gained from 22 via 23 and 24 and is O-protonated to 26.As shown by model reactions, primary 1,4-addition of enaminone nitrogen to p-benzoquinone is unlikely. - Keywords: Spirocyclization / Quinone cyclization / Enaminones / Nenitzescu reaction