121876-63-9

Upstream product

• 142-08-5 2-hydroxypyridin 
• 80056-43-5 (2-oxo-2H-pyridin-1-yl)-acetic acid ethyl ester 
• 941-69-5 N-phenyl-maleimide 
• 121876-59-3 2-dicyanomethylene-1,2-dihydro-1-ethoxycarbonylmethylpyridine 

Downstream Products

• 121876-67-3 C₂₂H₁₈N₄O₄ 
• 121876-67-3 N-phenyl-4-amino-5-cyano-3-ethoxycarbonyl-2-azatricyclo<5.2.2.0^2,6>undec-3,5,8-triene-10,11-exo-dicarboximide 

Relevant academic research and scientific papers

A SYNTHESIS OF A NEW TYPE HETEROCYCLIC COMPOUND USING DIELS-ALDER CYCLOADDITION OF 2-METHYLENE-1,2-DIHYDROPYRIDINES

Diels-Alder cycloaddition of 2-methylene-1,2-dihydropyridines having an active methylene group at the 1-position with N-phenylmaleimide gave isoquinuclidines, and cyclization of the adducts obtained afforded a new type of heterocyclic ring system, 2-azatricyclo2,6>undecanes.

A synthesis of a new-type heterocyclic compound by using Diels-Alder reaction of 2-methylene-1,2-dihydropyridine derivative

The Diels-Alder reaction of 2-dicyanomethylene-1,2-dihydropyridines having an active methylene group at the 1-position (Ia-d) with N-phenylmaleimide gave isoquinuclidine derivatives (IIa-d), which were treated with triethylamine to afford new-type heterocyclic ring system, 2-azatricyclo[5.2.2.02,6]undecane derivatives (IIIa-d).