1218764-57-8

Basic information

• Product Name: tert-butyl (3R,4R)-4-{[(2-chloroethyl)carbamoyl]amino}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate
• Synonyms: tert-butyl (3R,4R)-4-{[(2-chloroethyl)carbamoyl]amino}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate
• CAS NO: 1218764-57-8
• Molecular Weight: 450.793
• Mol File: 1218764-57-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: tert-butyl (3R,4R)-4-{[(2-chloroethyl)carbamoyl]amino}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (3R,4R)-4-{[(2-chloroethyl)carbamoyl]amino}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate(1218764-57-8)
• EPA Substance Registry System: tert-butyl (3R,4R)-4-{[(2-chloroethyl)carbamoyl]amino}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate(1218764-57-8)

Safety Data

• Hazardous Substances Data: 1218764-57-8(Hazardous Substances Data)

Upstream product

• 1943-83-5 2-chloroethyl isothiocyanate 
• 1160260-04-7 tert-butyl (3R,4R)-4-amino-3-(3,4-dichlorophenyl)piperidine-1-carboxylate p-toluenesulfonate 

Downstream Products

• 1218759-97-7 tert-butyl (3R,4R)-4-{3-[3,5-bis(trifluoromethyl)benzyl]-2-oxoimidazolidin-1-yl}-3-(3,4-dichlorophenyl)piperidine-1-carboxylate 
• 1218764-58-9 tert-butyl (3R,4R)-3-(3,4-dichlorophenyl)-4-(2-oxoimidazolidin-1-yl)piperidine-1-carboxylate 

Relevant articles and documents

NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND USE OF SAME

The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle; ring B is an aromatic ring optionally having substituent(s); ring D is an aromatic ring optionally having substituent(s); L is a group represented by the formula R2, R3, R4a and R4b are each independently a hydrogen atom, an optionally halogenated C1-6 alkyl group or an optionally halogenated C3-6 cycloalkyl group, or R2 and R3 are optionally bonded via an alkylene chain or an alkenylene chain, or R4a and R4b are optionally bonded via an alkylene chain or an alkenylene chain; R1 is a hydrogen atom or a substituent; m and n are each independently an integer of 0 to 5; m+n is an integer of 2 to 5; and- - - is a single bond or double bond, or a salt thereof; and the like. The compound has a superior tachykinin receptor antagonistic action, and is useful as an agent for the prophylaxis or treatment of various diseases such as lower urinary tract diseases, digestive tract diseases, central neurological disease and the like.