1218776-94-3Relevant articles and documents
Ultrasound-assisted one-pot green synthesis of new N- substituted-5-arylidene-thiazolidine-2,4-dione-isoxazoline derivatives using NaCl/Oxone/Na3PO4 in aqueous media
álvarez, Eleuterio,Arshad, Suhana,Bougrin, Khalid,El Alaoui, Nour-Eddine,Karrouchi, Khalid,Tachallait, Hamza,Talha, Aicha,Thari, Fatima Zahra
, (2020)
A rapid and green method for the synthesis of novel N-thiazolidine-2,4-dione isoxazoline derivatives 5 from N-allyl-5-arylidenethiazolidine-2,4-diones 3 as dipolarophiles with arylnitrile oxides via 1,3-dipolar cycloaddition reaction. The corresponding N-allyl substituted dipolarophiles were prepared by one-pot method from thiazolidine-2,4-dione with aldehydes using Knoevenagel condensation followed by N-allylation of thiazolidine-2,4-dione in NaOH aqueous solution under sonication. In addition, the isoxazoline derivatives 5 were synthesized by regioselective and chemoselective 1,3-dipolar cycloaddition using inexpensive and mild NaCl/Oxone/Na3PO4 as a Cl source, oxidant and/or catalyst under ultrasonic irradiation in EtOH/H2O (v/v, 2:1) as green solvent. All synthesized products are furnished in good yields in the short reaction time, and then their structures were confirmed by NMR, mass spectrometry and X-ray crystallography analysis.
Design, Synthesis and Biological Evaluation of New Piperazin-4-yl-(acetyl-thiazolidine-2,4-dione) Norfloxacin Analogues as Antimicrobial Agents
Marc, Gabriel,Araniciu, C?t?lin,Oniga, Smaranda Dafina,Vlase, Laurian,P?rn?u, Adrian,Nad??, George Cosmin,Novac, Cristiana ?tefania,Matei, Ioana Adriana,Chifiriuc, Mariana Carmen,M?ru?escu, Lumini?a,Oniga, Ovidiu
, (2019)
In an effort to improve the antimicrobial activity of norfloxacin, a series of hybrid norfloxacin–thiazolidinedione molecules were synthesized and screened for their direct antimicrobial activity and their anti-biofilm properties. The new hybrids were intended to have a new binding mode to DNA gyrase, that will allow for a more potent antibacterial effect, and for activity against current quinolone-resistant bacterial strains. Moreover, the thiazolidinedione moiety aimed to include additional anti-pathogenicity by preventing biofilm formation. The resulting compounds showed promising direct activity against Gram-negative strains, and anti-biofilm activity against Gram-positive strains. Docking studies and ADMET were also used in order to explain the biological properties and revealed some potential advantages over the parent molecule norfloxacin.
A Novel Magnetic Immobilized Para-Aminobenzoic Acid-Cu(II) Complex: A Green, Efficient and Reusable Catalyst for Aldol Condensation Reactions in Green Media
Esam, Zohreh,Akhavan, Malihe,Bekhradnia, Ahmadreza,Mohammadi, Masoud,Tourani, Saeed
, p. 3112 - 3131 (2020)
Abstract: In this the study a novel, efficient and recoverable heterogeneous nanocatalyst with regards to green chemistry purpose was approached. The structure of the newly synthesized heterogeneous magnetic nanocatalyst with enhanced and improved catalyt
