1218782-41-2Relevant academic research and scientific papers
Synthetic α-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation
Saraogi, Ishu,Hebda, James A.,Becerril, Jorge,Estroff, Lara A.,Miranker, Andrew D.,Hamilton, Andrew D.
supporting information; experimental part, p. 736 - 739 (2010/05/01)
Figure Presented Split personality: A series of oligoamidebased helix mimetics bind to a complementary helical motif in Islet amyloid polypeptide (IAPP), a protein implicated in the pathology of type II diabetes. These compounds accelerated IAPP amyloid formation under lipid-free conditions, but inhibited it under lipid-catalyzed conditions. hlAPP = human IAPP.
