1218783-79-9Relevant articles and documents
Catalytic, asymmetric indolizidinone aza-quaternary stereocenter synthesis: Expedient synthesis of the cylindricine alkaloid core
Dalton, Derek M.,Rovis, Tomislav
supporting information, p. 2346 - 2349 (2013/07/05)
The Rh(I)?CKphos catalyzed [2 + 2 + 2] cycloaddition of 1,1-disubstituted alkenyl isocyanates and alkyl alkynes selectively forms previously inaccessible vinylogous amide indolizidinone cycloadducts, establishing an aza-quaternery stereocenter with excellent enantioselectivities (up to 98% ee). This advance enables a seven step catalytic, asymmetric synthesis of the tricyclic core of the cylindricine alkaloids with excellent control of product selectivity as well as regio- and enantioselectivity.