1218792-28-9Relevant academic research and scientific papers
Novel small molecule bradykinin B1 receptor antagonists. Part 2: 5-membered diaminoheterocycles
Zischinsky, Gunther,Stragies, Roland,Schaudt, Marco,Pfeifer, Jochen R.,Gibson, Christoph,Locardi, Elsa,Scharn, Dirk,Richter, Uwe,Kalkhof, Holger,Dinkel, Klaus,Schnatbaum, Karsten
, p. 1229 - 1232 (2010)
Efforts to find new bradykinin B1 receptor antagonists identified 2-aminobenzimidazole as a novel core. Subsequent transformation into five-membered diaminoheterocycle derivatives and their synthesis and SAR is described. This resulted in compounds with low nanomolar activity.
