1218805-53-8Relevant articles and documents
Synthesis of novel pyrazoles via [2+3]-dipolar cycloaddition using alkyne surrogates
Dadiboyena, Sureshbabu,Valente, Edward J.,Hamme II, Ashton T.
, p. 1341 - 1343 (2010)
The syntheses of an important class of hitherto unreported novel pyrazoles are described. The regioselective synthesis of 1,3,4,5-tetrasubstituted pyrazoles was achieved by the Huisgen cyclization of nitrile imines with a trisubstituted bromoalkene. The substituted bromoalkene functions as an alkyne synthon which was used to construct 5,5-disubstituted bromopyrazoline intermediates that undergo aromatization to the analogous pyrazoles through the loss of HBr. The cycloaddition regioselectivity was confirmed through single X-ray crystal data of one of the pyrazoles.