1218811-71-2Relevant academic research and scientific papers
Copper-mediated direct cross-coupling of 1,3,4-oxadiazoles and oxazoles with terminal alkynes
Kitahara, Masanori,Hirano, Koji,Tsurugi, Hayato,Satoh, Tetsuya,Miura, Masahiro
experimental part, p. 1772 - 1775 (2010/06/14)
Copper-mediated direct cross-coupling of 1, 3, 4-oxadiazoles and oxazoles with terminal alkynes has been reported. The transition-metal-mediated direct functionalization reactions of C-H bonds have attracted significant interest in modern organic chemistry. The mixture was heated at 120°C, and the slow addition of 1 hour of a solution of phenylacetylene in DMAc (1.0 mL) as then started. The cross-coupling using CuCl2/DMEDA system. Thus, the desired 2-alkynyl-5-aryloxazoles were obtained by performing the reaction in a higher ratio at 150°C with DMSO as solvent. The oxadiazoles with various substituents at the 2-position were also available for use. 4- Methyl-, 4-methoxy-, 4-trifluoromethyl-, and 4-chloro- phenyl-1, 3, 4-oxadiazoles coupled with 4-MeC5H4, to furnish compound.
