1218817-65-2Relevant academic research and scientific papers
INHIBITORS OF SPHINGOSINE KINASE 1
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Page/Page column 123-124, (2010/04/25)
The invention relates to compounds of Formula (I). Compounds of the present invention are inliibitors of sphingosine kinase 3, and are useful in the treatment of various disorders and conditions, such as inflammatory disorders
Discovery of novel sphingosine kinase-1 inhibitors. Part 2
Xiang, Yibin,Hirth, Bradford,Kane Jr., John L.,Liao, Junkai,Noson, Kevin D.,Yee, Christopher,Asmussen, Gary,Fitzgerald, Maria,Klaus, Christine,Booker, Michael
scheme or table, p. 4550 - 4554 (2010/09/14)
Building on our initial work, we have identified additional novel inhibitors of sphingosine kinase-1 (SK1). These new analogs address the shortcomings found in our previously reported compounds. Inhibitors 51 and 54 demonstrated oral bioavailability in a
