1218918-62-7

Basic information

• Product Name: MK-7246
• Synonyms: MK-7246;(R)-2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid;ethyl 2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate;2-[(7R)-7-[(4-FLUOROPHENYL)SULFONYL-METHYLAMINO]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-10-YL]ACETIC ACID;(7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetic acid
• CAS NO: 1218918-62-7
• Molecular Formula: C₂₁H₂₁FN₂O₄S
• Molecular Weight: 416.4658432
• Mol File: 1218918-62-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 636.5±65.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• PKA: 4.50±0.10(Predicted)
• CAS DataBase Reference: MK-7246(CAS DataBase Reference)
• NIST Chemistry Reference: MK-7246(1218918-62-7)
• EPA Substance Registry System: MK-7246(1218918-62-7)

Safety Data

• Hazardous Substances Data: 1218918-62-7(Hazardous Substances Data)

Usage

Uses

MK-7246 is a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.

Upstream product

• 497922-82-4 ethyl 3-(6-oxo-1-phenyl-1,4,5,6-tetrahydropyridazin-3-yl)-propanoate 
• 1912-33-0 Indole-3-acetic acid methyl ester 
• 6317-49-3 4-oxopimelate 
• 87-51-4 indole-3-acetic acid 
• 1360470-68-3 methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate 
• 1218918-82-1 C₂₂H₂₃FN₂O₅S 
• 1218918-80-9 C₂₈H₃₉FN₂O₅SSi 
• 1360470-79-6 ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate 
• 1360470-78-5 ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate 
• 1360470-80-9 ethyl [(7R)-7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate hydrochloride 
• 1360470-77-4 ethyl (2-[4-[dimethyl(oxido)-λ4-sulfanylidene]-3-oxobutyl]-1H-indol-3-yl)acetate 
• 1360470-70-7 ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetate 
• 1360470-74-1 tert-butyl 10-(2-ethoxy-2-oxoethyl)-7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indole-6-carboxylate 
• 1360470-71-8 ethyl 3-(1-(2-(tert-butoxy)-2-oxoethyl)-3-(2-ethoxy-2-oxoethyl)-1H-indol-2-yl)propanoate 

Relevant articles and documents

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.

INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

The compound (+) {7R-[[(4-fluorophenyl)sulfonyl](methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-meidated diseases such as asthma.