1218918-73-0

Basic information

• Product Name: Propyl 7-aMino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate
• Synonyms: Propyl 7-aMino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate;propyl 2-[(7R)-7-amino-6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl]acetate
• CAS NO: 1218918-73-0
• Molecular Formula: C17H22N2O2
• Molecular Weight: 286.36878
• Mol File: 1218918-73-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Propyl 7-aMino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Propyl 7-aMino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate(1218918-73-0)
• EPA Substance Registry System: Propyl 7-aMino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate(1218918-73-0)

Safety Data

• Hazardous Substances Data: 1218918-73-0(Hazardous Substances Data)

Usage

General Description

Propyl 7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetate is a chemical compound with a complex molecular structure. It is an acetate derivative of 7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indole, which is a heterocyclic compound. This chemical may have potential pharmaceutical or research applications due to its unique structure and properties. Further study and analysis would be necessary to fully understand its potential uses and effects.

Upstream product

• 1218918-72-9 propyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate 

Downstream Products

• 1219007-86-9 C₂₄H₂₇FN₂O₂ 
• 1218918-74-1 propyl {(7R)-7-{[(4-fluorophenyl)sulfonyl]amino}-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetate 

Relevant articles and documents

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies leading to MK-7246 along with two synthetic sequences enabling the preparation of this novel class of CRTH2 antagonist are reported. Finally, the pharmacokinetic and metabolic profile of MK-7246 is disclosed.

INDOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS

The compound (+) {7R-[[(4-fluorophenyl)sulfonyl](methyl)ammo]-6,7,8,9-tetrahydropyrido[1,2-a]mdol-10-yl}acetic acid and pharmaceutically acceptable salts thereof are antagonists of the PGD2 receptor, CRTH2, and as such are useful in the treatment and/or prevention of CRTH2-meidated diseases such as asthma.