1218992-65-4Relevant academic research and scientific papers
Synthesis of a monophosphoryl derivative of Escherichia coli lipid A and Its efficient coupling to a tumor-associated carbohydrate antigen
Tang, Shouchu,Wang, Qianli,Guo, Zhongwu
experimental part, p. 1319 - 1325 (2010/06/14)
Monophosphoryl lipid A is a safe and potent immunostimulant and vaccine adjuvant, which is potentially useful for the development of effective carbohydrate-based conjugate vaccines. This paper presents a convergent and efficient synthesis of a monophosphoryl derivative of E. coli lipid A that has an alkyne functionality at the reducing end, which is suitable for coupling with various molecules. The coupling of this derivative to an N-modified analogue of tumor-associated antigen GM3 through click chemistry is also presented.
