1219004-75-7Relevant academic research and scientific papers
Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC
Warmus, Joseph S.,Quinn, Cheryl L.,Taylor, Clarke,Murphy, Sean T.,Johnson, Timothy A.,Limberakis, Chris,Ortwine, Daniel,Bronstein, Joel,Pagano, Paul,Knafels, John D.,Lightle, Sandra,Mochalkin, Igor,Brideau, Roger,Podoll, Terry
, p. 2536 - 2543 (2012/05/20)
Lipid A is an essential component of the Gram negative outer membrane, which protects the bacterium from attack of many antibiotics. The Lipid A biosynthesis pathway is essential for Gram negative bacterial growth and is unique to these bacteria. The firs
HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS
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Page/Page column 46, (2010/04/25)
The invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, thereof, wherein: G is a group of formula (II); and pharmaceutically acceptable salts, prodrugs, hydrates, or solvates, thereof, wherein A, B. L1-L4 A, B, R1-R4 and m are as defined herein. The invention also relates to pharmaceutical compositions comprising the compounds of formula (I) and their use in treating a bacterial infection.
