1219024-53-9Relevant articles and documents
PIPERIDINYLALKYLAMIDE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN
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Page/Page column 114-115, (2017/11/10)
The present invention relates to piperidinylalkylamide derivatives having dual pharmacological activity towards both the sigma (σ) receptor and the μ-opioid receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising
Two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles
Lefebvre, Valerie,Cailly, Thomas,Fabis, Frederic,Rault, Sylvain
supporting information; experimental part, p. 2730 - 2732 (2010/07/08)
A general two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles involving a palladium-catalyzed arylation of benzophenone hydrazone followed by an acidic deprotection/cyclization sequence is described. This procedure offers a general and efficient alternative to the typical S NAr reaction of hydrazine with o-fluorobenzonitriles.