1219032-18-4 Usage
Uses
Different sources of media describe the Uses of 1219032-18-4 differently. You can refer to the following data:
1. Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.
2. 9-Keto Travoprost is an impurity of Travoprost (T715600), a selective FP prostaglandin receptor agonist used to treat glaucoma (1,2).
Check Digit Verification of cas no
The CAS Registry Mumber 1219032-18-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,0,3 and 2 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1219032-18:
(9*1)+(8*2)+(7*1)+(6*9)+(5*0)+(4*3)+(3*2)+(2*1)+(1*8)=114
114 % 10 = 4
So 1219032-18-4 is a valid CAS Registry Number.
1219032-18-4Relevant articles and documents
PROCESS FOR PREPARING PROSTAGLANDIN DERIVATIVES
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Paragraph 86-88, (2010/10/03)
The present invention relates to a process for preparing a prostaglandin derivative and an intermediate therefor. In accordance with the present invention, the prostaglandin F (PGF) derivative can be efficiently prepared with high purity by removing the protecting group of a protected prostaglandin E (PGE) derivative obtained from conjugate addition and then stereoselectively reducing the ketone group on the cyclopentanone ring of the PGE derivative.