1219089-91-4

Basic information

• Product Name: 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-cytidine
• Synonyms: 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-cytidine
• CAS NO: 1219089-91-4
• Molecular Weight: 764.877
• Mol File: 1219089-91-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-cytidine(1219089-91-4)
• EPA Substance Registry System: 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N4-acetyl-cytidine(1219089-91-4)

Safety Data

• Hazardous Substances Data: 1219089-91-4(Hazardous Substances Data)

Upstream product

• 1219089-88-9 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N4-acetyl-cytidine 
• 85335-73-5 N₄-acetyl-3',5'-O-(tetraisopropyldisiloxane-1,3-diyl)cytidine 
• 1219089-90-3 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-N2-acetylcytidine 
• 40615-36-9 4,4'-dimethoxytrityl chloride 

Downstream Products

• 1219089-87-8 2'-O-(1,1-dioxo-1λ6-thiomorpholine-4-carbothioate)-5'-O-(4,4'-dimethoxytrityl)-N2-acetylcytidine-3'-O-(β-cyanoethyl)-N,N-diisopropylphosphoramidite 

Relevant articles and documents

Streamlined process for the chemical synthesis of RNA using 2-O-thionocarbamate-protected nucleoside phosphoramidites in the solid phase

An improved method for the chemical synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under anhydrous conditions. The process is compatible with most standard heterobase protection and employs a 2′-O-(1,1-dioxo- 1λ6-thiomorpholine-4-carbothioate) as a unique 2′-hydroxyl protective group. Using this approach, it was demonstrated that the chemical synthesis of RNA can be as simple and robust as the chemical synthesis of DNA.