1219092-51-9Relevant academic research and scientific papers
Catalytic asymmetric total synthesis of ent-hyperforin
Shimizu, Yohei,Shi, Shi-Liang,Usuda, Hiroyuki,Kanai, Motomu,Shibasaki, Masakatsu
, p. 1103 - 1106 (2010)
(Figure Presented) Key to success: The first catalytic asymmetric total synthesis of ent-hyperforin (see picture) was accomplished by using a Diels-Alder reaction promoted by a chiral cationic iron catalyst (A; 96% ee, d.r. >33:1), a diastereoselective Claisen rearrangement (B; 12:1 selectivity), an intramolecular aldol reaction (C), and a vinylogous Pummerer rearrangement (D) as key steps.
