1219095-87-0

Basic information

• Product Name: tert-butyl 2-methylpyridin-3-ylcarbamate
• Synonyms: tert-butyl 2-methylpyridin-3-ylcarbamate
• CAS NO: 1219095-87-0
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Mol File: 1219095-87-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: tert-butyl 2-methylpyridin-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-methylpyridin-3-ylcarbamate(1219095-87-0)
• EPA Substance Registry System: tert-butyl 2-methylpyridin-3-ylcarbamate(1219095-87-0)

Safety Data

• Hazardous Substances Data: 1219095-87-0(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-methylpyridin-3-ylcarbamate is a chemical compound that belongs to the family of N-alkylpyridines. These are compounds containing a pyridine ring, which is a six-membered aromatic heterocycle with one nitrogen atom and five carbon atoms, substituted by an alkyl group. In this case, the pyridine ring is substituted by a tert-butyl group at one position and a 2-methyl group at another position and has a carbamate group attached to it. It is generally used in intermediate stages of organic synthesis. The details regarding its physical and chemical properties, toxicology, or commercial uses are scarce; therefore, specialized literature should be consulted for a detailed understanding of this particular compound.

Upstream product

• 4248-19-5 tert-butyl carbazate 
• 38749-79-0 3-bromo-2-picoline 
• 3430-10-2 2-methyl-3-pyridinamine 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 1791402-58-8 tert-butyl N-[(2R,3R)-2-methylpiperidin-3-yl]carbamate 

Relevant articles and documents

Pd-catalyzed amidation of aryl(Het) halides with tert-butyl carbamate

Pd-catalyzed cross-coupling reaction of tert-butyl carbamate with various aryl(Het) halides with Cs2CO3 as base in 1,4-dioxane as solvent was investigated, which resulted in the formation of the desired compounds in moderate to excellent yields.

INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed herein are reversible and irreversible inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are describeded, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions.

HETEROCYCLIC TYROSINE KINASE INHIBITORS

The present invention provides compounds useful as inhibitors of Tec family kinases, compositions thereof, and methods of using the same. In certain embodiments, the present invention provides pharmaceutical formulations comprising provided compounds. In certain embodiments, the present invention provides a method of decreasing enzymatic activity of a Tec kinase family member. In some embodiments, such methods include contacting a Tec kinase family member with an effective amount of a Tec kinase family member inhibitor. In certain embodiments, the present invention provides a method of treating a disorder responsive to Tec kinase family inhibition in a subject in need thereof.