1219097-68-3Relevant academic research and scientific papers
Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation
Nair, Sajiv K.,Matthews, Jean J.,Cripps, Stephan J.,Ma, Chunrong,Dovalsantos, Elena Z.,Grubbs, Alan W.,Sach, Neal W.,Hoeve, Wolter ten,Koster, Han,Flahive, Erik J.,Tanis, Steven P.,Renner, Matt,Wiltenburg, Jim van
body text, p. 1451 - 1454 (2010/04/29)
A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastere
