1219102-34-7Relevant academic research and scientific papers
Synthesis, antimicrobial and antitubercular activity of some cyclohexenone and indazole derivatives
Vyas,Tala,Akbari,Dhaduk,Joshi
experimental part, p. 1405 - 1410 (2010/03/04)
The scries of compounds 6-carbethoxy-5-aryl-3-(3,5-dibromo-4-methoxy phenyl)-2-cyclohexenones 2a-j are obtained from the (2E)-1-(3,5-dibromo-4- methoxyphenyl)-3-aryl-prop-2-en-1-ones 1a-j by Michael addition of ethyl aeetoaeetatc. followed by internal Claisen condensation. Reaction of 2a-j with hydrazine hydrate afforded the corresponding 6-(3,5-dibromo-4-methoxyphcnyl)-4- aryl-2,3a,4,5-tetrahydro-3H-indazol-3-ones 3a-j. The constitution of all the synthesized compounds have been established by elemental analyses, IR, 1H NMR and mass spectral data. All the compounds have been screened for their antimicrobial activities and compounds 2a-j have been tested for antitubercular activity.
