1219112-85-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Bromo-6-chlorophenyl)-1,3-dihydro-2H-indol-2-one is used as a potential anti-inflammatory agent for the treatment of various inflammatory conditions. Its structural similarity to Diclofenac suggests that it may have similar COX inhibitory properties, which can help reduce inflammation and pain.
Used in Research Applications:
1-(2-Bromo-6-chlorophenyl)-1,3-dihydro-2H-indol-2-one can be used as a research tool to study the mechanisms of action of NSAIDs and COX inhibitors. It may also be used to investigate the structure-activity relationship of related compounds and to develop new drugs with improved efficacy and reduced side effects.

Upstream product

• 123790-84-1 (2-Bromo-6-chloro-phenyl)-phenyl-amine 

Relevant academic research and scientific papers

Synthesis and quantitative structure-activity relationships of diclofenac analogues

The synthesis of a series of 2-anilinophenylacetic acid, close analogues of diclofenac, is described. These compounds were tested in two models used for evaluating the activity of nonsteroidal antiinflammatory drugs (NSAID's), inhibition of cyclooxygenase enzyme activity in vitro, and adjuvant-induced arthritis (AdA) in rats. Statistically significant correlations were found between the inhibitory activities of the compounds in these two models, indicating that cyclooxygenase inhibition seems to be the underlying mechanism for the antiinflammatory activity of these compounds. Quantitative structure-activity relationship (QSAR) analysis revealed that the crucial parameters for activity in both models were the lipophilicity and the angle of twist between the two phenyl rings. Optimal activities were associated with halogen or alkyl substituents in both ortho positions of the anilino ring. Compounds with OH groups in addition to two ortho substituents or compounds with only one or no ortho substituents were less active.