1219130-56-9

Basic information

• Product Name: 2-dioxaborolan-2-yl)isoquinolin-1(2H)-one
• Synonyms: 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isoquinolin-1(2H)-One;(1-OXO-1,2-DIHYDROISOQUINOLIN-6-YL)BORONIC ACID PINACOL ESTER
• CAS NO: 1219130-56-9
• Molecular Formula: C15H18BNO3
• Molecular Weight: 271.13
• Product Categories: Organic boronic acid
• Mol File: 1219130-56-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 485.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3(Predicted)
• PKA: 12.41±0.20(Predicted)
• CAS DataBase Reference: 2-dioxaborolan-2-yl)isoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-dioxaborolan-2-yl)isoquinolin-1(2H)-one(1219130-56-9)
• EPA Substance Registry System: 2-dioxaborolan-2-yl)isoquinolin-1(2H)-one(1219130-56-9)

Safety Data

• Hazardous Substances Data: 1219130-56-9(Hazardous Substances Data)

Upstream product

• 147497-32-3 6-bromo-3,4-dihydroisoquinolin-1(2H)-one 
• 73183-34-3 bis(pinacol)diborane 
• 82827-09-6 6-bromo-2H-isoquinoline-1-one 

Downstream Products

• 1426083-11-5 6-{2-[4-(2-dimethylamino-ethoxy)-phenyl]-5-pyridin-4-yl-3H-imidazol-4-yl}-2H-isoquinolin-1-one 

Relevant articles and documents

COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PARASITIC DISEASES

The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease, such as malaria, caused by a Plasmodium parasite.

HETEROCYCLIC BIARYL DERIVATIVE AND PDE INHIBITOR COMPRISING SAME AS ACTIVE INGREDIENT

Novel heterocyclic biaryl derivatives were disclosed which are useful as pharmaceutical agents and which exhibit a phosphodiesterase-inhibitory action. The heterocyclic biaryl derivatives are represented by the following general formula (1): wherein the H