1219136-32-9Relevant academic research and scientific papers
Novel sulfur and selenium containing bis-α-amino acids from 4-hydroxyproline
Caputo, Romualdo,Dellagreca, Marina,De Paola, Ivan,Mastroianni, Domenico,Longobardo, Luigi
, p. 305 - 310 (2010)
The synthesis of new substituted prolines carrying at C-4 a second α-amino acid residue is reported. The amino acid, l-cysteine or l-selenocysteine, is linked to the proline ring through the sulfur or the selenium atom, respectively. The products were prepared with different stereochemistry at C-4, in few and clean high-yielding steps, with suitable protections for solid phase applications. The introduction of both sulfur and selenium atoms at C-4 of the proline ring seems to enhance significantly the cis geometry at the prolyl amide bond.
