1219138-73-4

Basic information

• Product Name: methyl (1R,2R)-2-(4-bromophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate
• Synonyms: methyl (1R,2R)-2-(4-bromophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate
• CAS NO: 1219138-73-4
• Molecular Weight: 348.196
• Mol File: 1219138-73-4.mol

Chemical Properties

• CAS DataBase Reference: methyl (1R,2R)-2-(4-bromophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (1R,2R)-2-(4-bromophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate(1219138-73-4)
• EPA Substance Registry System: methyl (1R,2R)-2-(4-bromophenyl)-1-cyano-3-formyl-4-methylcyclopent-3-enecarboxylate(1219138-73-4)

Safety Data

• Hazardous Substances Data: 1219138-73-4(Hazardous Substances Data)

Upstream product

• 1219138-77-8 methyl propargylcyanoacetate 
• 49678-04-8 4-bromocinnamaldeyde 
• 105515-33-1 3-(4-bromophenyl)prop-2-en-1-ol 

Downstream Products

• 1219138-83-6 5-(4-bromophenyl)-4-cyano-4-(methoxycarbonyl)-2-methylcyclopent-1-enecarboxylic acid 

Relevant articles and documents

The Use of Porous Palladium(II)-polyimine in Cooperatively- catalyzed Highly Enantioselective Cascade Transformations

Porous organic polymers have prospects as functional substrates for catalysis, with quite different molecular properties from inorganic substrates. Here we disclose for the first time that porous palladium(II)-polyimines are excellent catalysts for cooper

Enantioselective heterogeneous synergistic catalysis for asymmetric cascade transformations

A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non-metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5:2.5 er) as well as spirocyclic oxindoles (97.5:2.5 to >99:0.5 er), containing all-carbon quaternary centers, in a highly enantioselective fashion via a one-pot dynamic relay process.

Efficient and highly enantioselective aerobic oxidation-michael- carbocyclization cascade transformations by integrated Pd(0)-CPG nanoparticle/chiral amine relay catalysis

A series of highly diastereo- and enantioselective aerobic oxidation-Michael-carbocyclization cascade transformations by integrated heterogeneous Pd(0)-CPG nanoparticle/chiral amine relay catalysis are disclosed. The heterogeneous Pd(0)-CPG nanoparticle catalysts were efficient for both the sequential aerobic oxidation and dynamic kinetic asymmetric Michael- carbocyclization transformations, resulting in 1) oxidation of a variety of allylic alcohols to enals and 2) formation of cyclopentenes containing an all-carbon quaternary stereocenter in good to high yields with up to 20:1 dr and 99.5:0.5 er. Georg Thieme Verlag Stuttgart.New York.

Dynamic kinetic asymmetrie iransformation (DYKAT) by combined amine- And transition-metal-catalyzed enantioselective cvcloisomerization

The first examples of one-pot highly chemo- and enantioselective dynamic kinetic asymmetric transformations (DYKATs) involving ot,ss-unsaturated aldehydes and propargylated carbon acids are presented. These DYKATs, which proceed by a combination of catalytic iminium activation, enamine activation, and Pd-catalyzed enyne cycloisomerization, give access to functionalized cyclopentenes with up to 99% ee and can be used for the generation of all-carbon quaternary stereocenters.