1219143-85-7

Basic information

• Product Name: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid
• Synonyms: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;alpha-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-1H-pyrrolo[2,3-b]pyridine-3-propanoic acid;(S)-N-FMoc-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;2-(FMOC-AMINO)-3-(1H-PYRROLO[2,3-B]PYRIDIN-3-YL)PROPANOIC ACID
• CAS NO: 1219143-85-7
• Molecular Formula: C25H21N3O4
• Molecular Weight: 427.45194
• Mol File: 1219143-85-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.382
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid(1219143-85-7)
• EPA Substance Registry System: 2-((((9H-fluoren-9-yl)Methoxy)carbonyl)aMino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid(1219143-85-7)

Safety Data

• Hazardous Substances Data: 1219143-85-7(Hazardous Substances Data)

Usage

Uses

2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic Acid is used as a reactant in the synthesis of template-fixed β-hairpin peptidomimetics as CCR10 antagonists.

Upstream product

• 82911-69-1 N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide 

Relevant articles and documents

Asymmetric Synthesis of N-Fmoc-(S)-7-aza-tryptophan via Alkylation of Chiral Nucleophilic Glycine Equivalent

Ni(II)-complexes, derived from glycine Schiff bases with chiral tridentate ligands, have been used as powerful tools for the synthesis of structurally diverse tailor-made amino acids. In this manuscript, asymmetric alkylation reaction between chiral nucleophilic glycine derived Ni-complex and 3-(chloromethyl)-1H-pyrrolo[2,3-b]pyridine has been developed under convenient conditions, which affords the corresponding alkylated Ni-complex in 74 % yield and excellent diastereoselectivity (only one isomer). This reaction features convenient conditions and completely controlled diastereoselectivity, which provides a highly valuable approach for asymmetric synthesis of 7-aza-tryptophan.