1219198-88-5

Basic information

• Product Name: Methyl 2-amino-2-(3-bromophenyl)acetate HCl
• Synonyms: Methyl 2-amino-2-(3-bromophenyl)acetate HCl;Methyl a-amino-3-bromobenzeneacetate HCl
• CAS NO: 1219198-88-5
• Molecular Formula: C₉H₁₀BrNO₂*ClH
• Molecular Weight: 280.56
• Mol File: 1219198-88-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 210℃
• Appearance: /
• CAS DataBase Reference: Methyl 2-amino-2-(3-bromophenyl)acetate HCl(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-amino-2-(3-bromophenyl)acetate HCl(1219198-88-5)
• EPA Substance Registry System: Methyl 2-amino-2-(3-bromophenyl)acetate HCl(1219198-88-5)

Safety Data

• Hazardous Substances Data: 1219198-88-5(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 79422-73-4 α-amino-3-bromophenylacetic acid 
• 3132-99-8 m-bromobenzoic aldehyde 

Downstream Products

• 1132817-76-5 Methyl 2-amino-2-(3-bromophenyl)acetate 

Relevant articles and documents

Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)-H Carbonylation of Phenylglycinol Derivatives

An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)-H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group is demonstrated. The reaction proceeds in the presence of a commercially available cobalt(II) tetramethylheptanedionate catalyst and employs DIAD as a "CO" surrogate. This synthetic route offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry. Besides, the developed method provides a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.