1219213-68-9Relevant academic research and scientific papers
Synthesis of N-(phosphonomethyl)glycine derivatives and studies of their immunotropic activity
Shevchuk,Metelitsa,Charochkina,Mogilevich,Rusanov,Sorochinsky,Khilya,Romanenko,Kukhar
, p. 712 - 718 (2011)
The Petasis reaction between glyoxylic acid, α-amino phosphonates, and organylboronic acid afforded N-phosphonomethyl-α-amino acids. This method has an advantage of preparative simplicity and high diastereoselectivity of the reactions. Immunotropic activity of the synthesized compounds was studied using the models in vivo.
Utilization of aminophosphonates in the petasis boronic acid mannich reaction
Shevchuk, Michael V.,Sorochinsky, Alexander E.,Khilya, Volodymyr P.,Romanenko, Vadim D.,Kukhar, Valery P.
supporting information; experimental part, p. 73 - 76 (2010/08/19)
Aminophosphonates were used as amine components in the Petasis boronic acid Mannich reaction. With the use of α-aminophosphonates, several N-phosphonomethylglycine derivatives were prepared in modest to good yields and high diastereoselectivities. The met
