1219442-07-5Relevant academic research and scientific papers
Synthesis and biological activity of analogs of CPZEN-45, a novel antituberculosis drug
Ishizaki, Yoshimasa,Takahashi, Yoshiaki,Kimura, Tomoyuki,Inoue, Michitaka,Hayashi, Chigusa,Igarashi, Masayuki
, p. 970 - 980 (2019)
Analogs of CPZEN-45, which is expected to be a promising new antituberculosis drug that overcomes the shortcomings of caprazamycins, were synthesized and their biological activities were evaluated. The biological activity of analogs 1–3, which converted the anilide portion, and analogs 4 and 5, focusing on the seven-membered ring, were lower than that of CPZEN-45. These results suggest that the inhibitory activity of CPZEN-45 against TagO, an ortholog of WecA, has a strict structural limitation, and it was hoped for elucidation of the mode of action of CPZEN-45 using structural biology in the future.
ANTI-XDR-TB AGENT, ANTI-MDR-TB AGENT, AND COMBINED ANTI-TUBERCULOUS AGENT
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, (2011/08/04)
An anti-XDR-TB drug including a compound having a structure expressed by Structural Formula (1) below; an anti-MDR-TB drug including a compound having a structure expressed by Structural Formula (1) below; and a combination anti-tuberculosis drug includin
Antibacterial agent and therapeutic agent for Johne's disease containing the same
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Page/Page column 17-18, (2009/09/05)
An antibacterial agent having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is provided. Specifically, the antibacterial agent of the present invention having high antibacterial activity against Mycobacterium avium subsp. paratuberculosis is a caprazamycin derivative represented, for example, by the following general formula (II): wherein Me is a methyl group; and R1 is a straight or substantially straight chain alkyl group having 5 to 21 carbon atoms, a straight or substantially straight chain alkenyl group having 5 to 21 carbon atoms, a cycloalkyl group having 5 to 12 carbon atoms, or a phenyl group substituted at the para-position with a straight chain alkyl group having 1 to 14 carbon atoms, a straight chain alkoxy group having 1 to 9 carbon atoms or a cycloalkyl group having 5 to 12 carbon atoms.
