1219446-95-3Relevant academic research and scientific papers
Organocatalyzed Enantioselective Synthesis of 2-Amino-4H-chromene Derivatives
Ramireddy, Naresh,Abbaraju, Santhi,Ding, Derong,Arman, Hadi,Zhao, John C.-G.
, p. 677 - 691 (2017/02/03)
Optically active 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylates, 2-amino-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles, and 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles were synthesized. Using cinchona alkaloid-derived bifunctional catalysts, the corresponding 2-amino-4H-chromene derivatives were obtained in high yields and moderate to high ee values (up to 82% ee) from the tandem Michael addition–cyclization reaction between 1,3-cyclohexanediones or 1,2-cyclohexanediones and (E)-3-aryl-2-cyanoacrylate or alkylidene malononitrile derivatives.
Organocatalyzed synthesis of 2-amino-8-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitriles
Ding, Derong,Zhao, Cong-Gui
scheme or table, p. 1322 - 1325 (2010/04/29)
2-Amino-8-oxo-tetrahydro-4H-chromene-3-carbonitriles were synthesized for the first time from a tandem Michael addition-cyclization reaction between cyclohexane-1,2-dione and benzylidenemalononitriles. An enantioselective synthesis of these compounds was achieved in moderate ee values (up to 63% ee) by using a cinchona alkaloid-derived thiourea catalyst.
