1219449-45-2

Upstream product

• 1219449-56-5 sodium hydroxy(2-(pyrrolidin-1-ylsulfonyl)phenyl)methanesulfonate 

Downstream Products

• 1219450-68-6 3-(hydroxy(2-(pyrrolidin-1-ylsulfonyl)phenyl)methyl)-2-methyl-6,7-dihydro-1H-indol-4(5H)-one 
• 1219450-00-6 3-(hydroxy(2-(pyrrolidin-1-ylsulfonyl)phenyl)methyl)-2,6,6-trimethyl-6,7-dihydro-1H-indol-4(5H)-one 
• 1219449-44-1 ethyl 2-(2,5,5-trimethyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-4,5,6,7-tetrahydro-1H-indol-1-yl)acetate 
• 1312717-90-0 2,4-dimethyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrole 
• 1312717-89-7 3,5-dimethyl-2-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrole 
• 1312717-72-8 ethyl 2-(5-cyclohexyl-2-methyl-3-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate 
• 1312717-32-0 2-(3-cyano-2,5-dimethyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetic acid 
• 1312717-33-1 Ethyl 2-(3-cyano-2,5-dimethyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-1H-pyrrol-1-yl)acetate 
• 1355613-58-9 (5-methyl-4H-pyrroIo[2,3-d]thiazol-6-yl)(2-(pyrrolidin-1-ylsulfonyl)phenyI)methanol 
• 1355613-53-4 5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-6H-thieno[2,3-b]pyrrole 
• 1355613-49-8 2-(5-methyl-6-(2-(pyrrolidin-1-yIsulfonyl)benzyl)-4H-pyrrolo[2,3-d]thiazol-4-yl)acetic acid 
• 1355613-61-4 ethyl 2-(5-methyl-6-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-4H-pyrrolo[2,3-d]thiazol-4-yl)acetate 
• 1355613-59-0 5-methyl-6-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-4H-pyrrolo[2,3-d]thiazole 
• 1355613-47-6 2-(5-methyl-4-(2-(pyrrolidin-1-ylsulfonyl)benzyl)-6H-thieno[2,3-b]pyrrol-6-yl)acetic acid 

Relevant academic research and scientific papers

CRTH2 MODULATORS AND PREPARATION THEREOF

The present invention relates to processes and intermediates for the preparation of compounds useful as CRTH2 antagonists. Compounds prepared by the processes of the invention are of Formula (AI), (All) and Compound (I).

CRTH2 MODULATORS

Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I