1219468-13-9

Basic information

• Product Name: N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine
• Synonyms: N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine
• CAS NO: 1219468-13-9
• Molecular Weight: 264.327
• Mol File: 1219468-13-9.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine(1219468-13-9)
• EPA Substance Registry System: N-benzoylimino-3,4-dihydro-5-methylisoquinolinium betaine(1219468-13-9)

Safety Data

• Hazardous Substances Data: 1219468-13-9(Hazardous Substances Data)

Upstream product

• 1219468-04-8 2-(2-bromoethyl)-3-methylbenzaldehyde 
• 613-94-5 benzoic acid hydrazide 
• 180624-85-5 1-[2-(2-Methoxy-ethoxymethoxy)-ethyl]-2-methyl-benzene 
• 103839-04-9 3,4-dihydro-1-methoxy-5-methyl-1H-isochromene 
• 103839-06-1 3,4-dihydro-5-methyl-2(1H)-benzopyran 
• 1032509-63-9 1-(2-(methoxymethoxy)ethyl)-2-methylbenzene 
• 19819-98-8 2-o-tolylethanol 
• 644-36-0 o-methylphenylacetic acid 

Relevant articles and documents

A rhodium-catalysed three-component reaction to access C1-substituted tetrahydroisoquinolines

A rhodium-catalyzed three-component reaction of diazo compounds, anilines and C,N-cyclic azomethine imines via trapping of transient ammonium ylides was developed. This reaction provided a simple and convenient approach for the synthesis of pharmaceutically intriguing tetrahydroisoquinoline derivatives in moderate to good yields (36-85%) with good diastereoselectivities (up to 95 : 5 dr) under mild reaction conditions.

Chiral Phosphoric Acid-Catalyzed Enantioselective Formal [3+2] Cycloaddition of Azomethine Imines with Enecarbamates

The first catalytic asymmetric inverse electron demand 1,3-dipolar cycloaddition of azomethine imines with enecarbamates has been developed. Isoquinoline-fused pyrazolidines containing two or three contiguous stereogenic centers were obtained in high yields with excellent regio-, diastereo-, and enantioselectivities. The pyrazolidine ring can be opened to install an aminal, α-amino nitrile, or homoallylamine function with an excellent control of the newly generated stereogenic center. Access to aminobenzo[a]quinolizidine is also documented. Acid catalysis: The first catalytic asymmetric inverse electron demand 1,3-dipolar cycloaddition of azomethine imines with enecarbamates has been developed. Isoquinoline-fused pyrazolidines containing two or three contiguous stereogenic centers were obtained in high yields with excellent regio-, diastereo-, and enantioselectivities (see scheme).

Thermal 1,3-dipolar cycloaddition reaction of azomethine imines with active esters

An efficient method for the 1,3-dipolar cycloaddition of azomethine imines with active esters under thermal conditions has been described in good to high yields. This method offers a straightforward pathway to synthesize bioactive pyrazolidinones.