1219602-91-1Relevant articles and documents
Synthesis and biological evaluation of antitumour-active betulin derivatives
Csuk, René,Barthel, Alexander,Kluge, Ralph,Str?hl, Dieter,Kommera, Harish,Paschke, Reinhard
, p. 1344 - 1355 (2010)
The reaction of betulinic aldehydes with various carbon nucleophiles gave a series of new betulin derivatives, among them epoxides, glycidic derivatives and β-hydroxy carbonyl compounds. Subsequent transformations of the β-hydroxy carbonyls lead to 1,3-diketo- and α,β-unsaturated betulin derivatives. These compounds were assayed for cytotoxicity using 15 human cancer cell lines and a colorimetric SRB-assay. Several compounds revealed significant antitumour activity.