1219617-95-4Relevant academic research and scientific papers
Michael addition-lactonization reaction of electron-deficient alkynes with n-(Diphenylmethylene)glycinates: An efficient synthesis of 3-Amino-2-pyrone Derivatives
Zhou, Qing-Fa,Zhu, Yong,Tang, Wei-Fang,Lu, Tao
, p. 211 - 216 (2010)
A mild and efficient process for the synthesis of 3-amino-2-pyrone derivatives has been developed. This approach is based on the Michael addition of N-(diphenylmethylene)glycinates to various alkynyl ketones, followed by lactonization using 10 mol% sodium hydroxide as catalyst. Aromatic and aliphatic alkynyl ketones were converted into the corresponding 3-amino-2-pyrone derivatives in moderate to high yields. When methyl propiolate was submitted to the reaction,α,β-dehydroamino acids were formed in good yields. Georg Thieme Verlag Stuttgart.
