1219696-99-7

Basic information

• Product Name: (2S)-2-[(5S,7S)-7-(4-phenylethylpiperazine-1-carbonyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-3-yl]-4-methylpentanoic acid methyl ester
• CAS NO: 1219696-99-7
• Molecular Weight: 473.569
• Mol File: 1219696-99-7.mol

Chemical Properties

• CAS DataBase Reference: (2S)-2-[(5S,7S)-7-(4-phenylethylpiperazine-1-carbonyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-3-yl]-4-methylpentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-2-[(5S,7S)-7-(4-phenylethylpiperazine-1-carbonyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-3-yl]-4-methylpentanoic acid methyl ester(1219696-99-7)
• EPA Substance Registry System: (2S)-2-[(5S,7S)-7-(4-phenylethylpiperazine-1-carbonyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]oct-3-yl]-4-methylpentanoic acid methyl ester(1219696-99-7)

Safety Data

• Hazardous Substances Data: 1219696-99-7(Hazardous Substances Data)

Upstream product

• 1219696-68-0 C₁₉H₃₁NO₁₁ 
• 1219696-69-1 C₁₅H₂₅NO₈ 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 5321-49-3 4-(phenethyl)piperazine 
• 1219696-70-4 (1S,5R,7S)-3-(1-methoxycarbonyl-3(S)-methylbutyl)-2-oxo-6,8-dioxa-3-azabicyclo[3.2.1]octane-7-carboxylic acid methyl ester 

Relevant articles and documents

Identification of inhibitors of drug-resistant Candida albicans strains from a library of bicyclic peptidomimetic compounds

The screening of a library of small molecule peptidomimetics toward secreted aspartic proteinase-2 (SAP2) of Candida albicans allowed us to identify two compounds that showed in vitro inhibitory potency comparable to pepstatin A. In an experimental model of vaginal candidiasis, the two candidate compounds were as active as a therapeutic dose of fluconazole. Importantly, this activity was fully preserved when the challenger was a fluconazole-resistant strain of the fungus. Altogether, our data demonstrate SAP2 as a valid C. albicans target for the development of new drugs against this important human pathogen.