1219741-22-6

Basic information

• Product Name: 6-chloro-5-iodo-2-(Methylthio)-1H-benziMidazole
• Synonyms: 6-chloro-5-iodo-2-(Methylthio)-1H-benziMidazole;6-Chloro-5-iodo-2-(methylthio)-1H-benzo[d]imidazole;5-chloro-6-iodo-2-(methylthio)-1H-benzo[d]imidazole
• CAS NO: 1219741-22-6
• Molecular Formula: C₈H₆ClIN₂S
• Molecular Weight: 324.56911
• EINECS: -0
• Mol File: 1219741-22-6.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 6-chloro-5-iodo-2-(Methylthio)-1H-benziMidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-5-iodo-2-(Methylthio)-1H-benziMidazole(1219741-22-6)
• EPA Substance Registry System: 6-chloro-5-iodo-2-(Methylthio)-1H-benziMidazole(1219741-22-6)

Safety Data

• Hazardous Substances Data: 1219741-22-6(Hazardous Substances Data)

Usage

Substituents

Chloro on 5th carbon atom
Iodo on 6th carbon atom
Methylthio group on 2nd carbon atom
Potential applications in pharmaceutical and research industries

Biological activities

Anti-cancer
Anti-inflammatory
Antimicrobial
Unique reactivity and selectivity in chemical reactions
Valuable building block for organic synthesis
Possibility for discovery of novel drugs and materials with important industrial or medical applications.

Upstream product

• 1219741-21-5 3,5-chloro-6-iodo-1,3-dihydro-2H-benzimidazole-2-thione 
• 74-88-4 methyl iodide 
• 1219741-20-4 2, 4-chloro-5-iodobenzene-1,2-diamine 
• 335349-57-0 2-nitro-4-iodo-5-chloroaniline 
• 1635-61-6 5-chloro-2-nitroaniline 
• 1219741-21-5 5-chloro-6-iodo-2,3-dihydro-1H-1,3-benzodiazole-2-thione 

Downstream Products

• 1219741-57-7 methyl 5-[(5-biphenyl-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methylbenzoate 
• 1219741-71-5 methyl 5-[(6-chloro-5-(1-methyl-1H-indol-5-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl)oxy]-2-methylbenzoate 
• 1219737-74-2 3-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1Hbenzo[d]imidazol-2-yl)thio)benzoic acid 
• 1219741-39-5 methyl 5-[(6-chloro-5-iodo-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazol-2-yl)oxy]-2-methylbenzoate 
• 1219737-12-8 5-((5-([1,1'-biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid 
• 1219739-36-2 5-((6-chloro-5-(1-methyl-1H-indol-5-yl)-1H-benzo[d]-imidazol-2-yl)oxy)-2-methylbenzoic acid 
• 1332706-74-7 1-({[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}methyl)cyclopropane carboxylic acid 
• 1332707-02-4 methyl 1-({[5-(biphenyl-4-yl)-6-chloro-1-(prop-2-en-1-yl)-1H-benzimidazol-2-yl]oxy}methyl)cyclopropanecarboxylate 
• 1332706-65-6 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2yl]oxy}cyclobutanecarboxylic acid 
• 1332706-96-3 ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]-methyl}-1H-benzimidazol-2-yl]oxy}cyclobutanecarboxylate 
• 1332706-64-5 3-{[5-(biphenyl-4-yl)-6-chloro-1H-benzimidazol-2-yl]oxy}cyclopentane carboxylic acid 
• 1332706-95-2 ethyl 3-{[5-(biphenyl-4-yl)-6-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-benzimidazol-2-yl]oxy}cyclopentanecarboxylate 

Relevant articles and documents

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such,

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK- activated protein kinase. The compounds of the present invention are useful in

NOVEL CYCLIC BENZIMIDAZOLE DERIVATIVES USEFUL ANTI-DIABETIC AGENTS

Novel compounds of the structural formula (I) are activators of AMP-protein kinase and are useful in the treatment, prevention and suppression of diseases mediated by the AMPK-activated protein kinase. The compounds of the present invention are useful in the treatment of Type 2 diabetes, hyperglycemia, Metabolic Syndrome, obesity, hypercholesterolemia, and hypertension