1219741-50-0 Usage
Description
6-Bromo-3-methyl-1H-indole is a chemical compound with the molecular formula C9H8BrN. It is a derivative of indole, a heterocyclic organic compound commonly found in plants and used in the synthesis of various pharmaceuticals. This specific compound is characterized by a bromine atom and a methyl group attached to the indole ring, and it is used in research and chemical synthesis as a building block for the production of other organic compounds. Its properties and potential applications are of interest to chemists and researchers in various fields, including medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Industry:
6-Bromo-3-methyl-1H-indole is used as a building block in the synthesis of various pharmaceuticals for its unique chemical properties and potential therapeutic applications.
Used in Medicinal Chemistry Research:
6-Bromo-3-methyl-1H-indole is used as a research compound in medicinal chemistry to explore its potential as a precursor for the development of new drugs and therapeutic agents.
Used in Chemical Synthesis:
6-Bromo-3-methyl-1H-indole is used as a chemical intermediate in the synthesis of other organic compounds, leveraging its unique structural features and reactivity.
Check Digit Verification of cas no
The CAS Registry Mumber 1219741-50-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,7,4 and 1 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1219741-50:
(9*1)+(8*2)+(7*1)+(6*9)+(5*7)+(4*4)+(3*1)+(2*5)+(1*0)=150
150 % 10 = 0
So 1219741-50-0 is a valid CAS Registry Number.
1219741-50-0Relevant articles and documents
INHIBITORS OF ENL/AF9 YEATS
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Paragraph 00231-00232, (2021/06/26)
Methods and compositions for treating leukemia are disclosed. Acylated 6-aminoindoles, acylated 6-aminopyrrolopyridines and acylated 3-aminopyrrolo[3,2-c]pyridazines of the following formula inhibit ENL/AF9 YEATS and are therefore useful for treating leukemia.
Organocatalytic Formal (3 + 2) Cycloaddition toward Chiral Pyrrolo[1,2- a]indoles via Dynamic Kinetic Resolution of Allene Intermediates
Bai, Jian-Fei,Zhao, Lulu,Wang, Fang,Yan, Fachao,Kano, Taichi,Maruoka, Keiji,Li, Yuehui
supporting information, p. 5439 - 5445 (2020/07/14)
We report the chiral phosphoric acid catalyzed formal (3 + 2) cycloaddition of 3-substituted 1H-indoles and propargylic alcohols containing a functional directing group (p-NHAc or p-OH). This work represents a straightforward method to synthesize chiral pyrrolo[1,2-a]indole bearing a tetrasubstituted carbon stereocenter. The reaction proceeds smoothly with a wide array of substrate tolerance to deliver various chiral pyrrolo[1,2-a]indoles in up to 93percent yield and 98percent ee. The utility of this method is highlighted by the diverse transformations of the products into various indole derivatives.
New method for synthesis of EZH2 methyltransferase inhibitor GSK126
Lu, Chen,Zhang, Qiang,Chen, Xin
, p. 1215 - 1222 (2016/08/05)
GSK126 is a potent small-molecule inhibitor of S-adenosyl-methionine-competitive EZH2 methyltransferase and has the potential to be used clinically for preventing unwanted histone methylation of tumor suppressor genes. In this article, we describe a new s
