1219799-25-3Relevant academic research and scientific papers
Fungal Biosynthesis of 3-Nitropropanoic Acid
Baxter, Robert L.,Hanley, A. Bryan,Chan, Henry W.-S.,Greenwood, Suzanne L.,Abbot, Elaine M.,et al.
, p. 2495 - 2502 (2007/10/02)
The origin of 3-nitropropanoic acid 1 in the fungus Penicillium atrovenetum has been examined using a combination of stable isotope methods.The incorporation of 13C and 15N from DL-aspartic acid 2a, 18O from 18O2, 15N from DL-diethyl nitrosuccinate 6 and 2H from L-aspartate, DL-aspartate and from (2S,3R)-- and (2S,3S)--aspartates indicate a biosynthetic pathway L-aspartate 2 -> (S)-nitrosuccinate 5 -> 1.Mature cells of P. atrovenetum which produce 3-nitropropanoate dehydrogenase catalyse an apparent futile cycle between 1 and 3-nitroacrylate 3 with loss of the stereospecific integrity of the hydrogen at the 2-position of 1.
