121980-44-7

Basic information

• Product Name: methyl (3R)-3-<(t-butyl)dimethylsilyloxy>hex-5-enoate
• Synonyms: methyl (3R)-3-<(t-butyl)dimethylsilyloxy>hex-5-enoate
• CAS NO: 121980-44-7
• Molecular Weight: 258.433
• Mol File: 121980-44-7.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: methyl (3R)-3-<(t-butyl)dimethylsilyloxy>hex-5-enoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (3R)-3-<(t-butyl)dimethylsilyloxy>hex-5-enoate(121980-44-7)
• EPA Substance Registry System: methyl (3R)-3-<(t-butyl)dimethylsilyloxy>hex-5-enoate(121980-44-7)

Safety Data

• Hazardous Substances Data: 121980-44-7(Hazardous Substances Data)

Upstream product

• 181272-46-8 (2R)-1-cyano-2-hydroxy-4-pentene 
• 197899-19-7 (2R)-1-chloro-2-hydroxy-4-pentene 
• 866455-76-7 (3R)-5-hexene-1,3-diol 
• 1313835-58-3 (5R)-2,2,3,3,9,9,10,10-octamethyl-5-(prop-2-en-1-yl)-4,8-dioxa-3,9-disilaundecane 
• 1275506-53-0 (R)-3-((tert-butyldimethylsilyl)oxy)hex-5-enal 
• 1275506-51-8 (3R)-3-{[(tert-butyl)(dimethyl)silyl]oxy}hex-5-en-1-ol 
• 186581-53-3 diazomethane 
• 121772-43-8 (3R)-3-hex-5-enoic acid 
• 109462-44-4 (R)-3-hydroxy-5-hexenoic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 1313835-56-1 methyl (3R,5E,7S)-3,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}-7-phenylhept-5-enoate 
• 1313835-59-4 dimethyl (3R,5E,8R)-3,8-bis{[(tert-butyl)(dimethyl)silyl]oxy}dec-5-enedioate 
• 1313835-55-0 methyl (3R,5R,6S,7R)-3,7-bis{[(tert-butyl)(dimethyl)silyl]oxy}-5,6-dihydroxy-7-phenylheptanoate 
• 147118-35-2 methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate 
• 121980-48-1 (Z)-(R)-3-Hydroxy-7-phenyl-hept-5-enoic acid 
• 70633-86-2 (4R,6R,1'E)-4-hydroxy-6-(2'-phenylvinyl)-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 70633-85-1 (4R,6S,1'E)-4-hydroxy-6-(2'-phenylvinyl)-3,4,5,6-tetrahydro-2H-pyran-2-one 
• 121980-49-2 (R)-4-Hydroxy-6-(2-phenyl-1-phenylselanyl-ethyl)-tetrahydro-pyran-2-one 
• 121980-46-9 methyl (3R)-3-<(t-butyl)dimethylsilyloxy>-7-phenylhept-5-enoate 
• 122046-62-2 (S)-goniothalamin 
• 22639-28-7 (R)-goniothalamin 
• 133961-74-7 methyl (3R)-3-hydroxy-7-phenylhept-5-enoate 
• 121980-48-1 (3R)-3-hydroxy-7-phenylhept-5-enoic acid 

Relevant articles and documents

ROSUVASTATIN CALCIUM INTERMEDIATE AND PREPARATION METHOD THEREOF

A rosuvastatin calcium intermediate as shown by Formula I is prepared as follow: a) subjecting chloroethylene, magnesium and R-epoxy chloropropane to Grignard reaction, b) adding sodium cyanide for nucleophilic substitution reaction, c) adding alcohol for alcoholysis reaction, d) adding alkaline solvent for hydroxyl protection, e) subjecting the mixture to oxidation reaction, f) adding triphenyl phosphorus and subjecting to Wittig reaction in the presence of alkali to obtain the compound of formula I. The method has moderate reaction conditions, is convenient and stable and can be applied to industrial production.

Total synthesis of leiocarpin C and (+)-goniodiol via an olefin cross-metathesis protocol

A stereoselective total synthesis of leiocarpin C (2) and (+)-Goniodiol (1) by applying olefin cross-metathesis and substrate directed dihydroxylation as the key steps is reported (Schemea 3).

An alternative approach to mevinic acid analogues from methyl (3R)-3-hydroxy-5-hexenoate and an extension to rational syntheses of (+)-(6R)-goniothalamin and its non-natural (-)-(6S)-enantiomer

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