1219801-75-8

Upstream product

• 637-69-4 4-Methoxystyrene 
• 50-00-0 formaldehyd 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 1418210-09-9 methyl 2-acetyl-5-(4-methoxyphenyl)-5-[4-(dimethylamino)phenyl]pentanoate 
• 1418210-10-2 methyl 2-acetyl-5-(4-methoxyphenyl)-5-[4-(N-methylamino)phenyl]pentanoate 
• 1418210-11-3 methyl 2-acetyl-5-(2-hydroxynaphthalen-1-yl)-5-(4-methoxyphenyl)pentanoate 
• 1354642-06-0 methyl 2-acetyl-5-(4-methoxyphenyl)-5-(o-tolylthio)pentanoate 
• 1354642-10-6 methyl 2-acetyl-5-[(4-chlorophenyl)thio]-5-(4-methoxyphenyl)pentanoate 
• 1354642-05-9 methyl 2-acetyl-5-(4-methoxyphenyl)-5-(phenylthio)pentanoate 
• 1354642-04-8 methyl 2-acetyl-5-[(3,5-dimethylphenyl)thio]-5-(4-methoxyphenyl)pentanoate 
• 1354642-09-3 methyl 2-acetyl-5-(4-methoxyphenyl)-5-[(2-methoxyphenyl)thio]pentanoate 
• 1354642-07-1 methyl 2-acetyl-5-[(2,4-dimethylphenyl)thio]-5-(4-methoxyphenyl)pentanoate 
• 1354642-08-2 methyl 2-acetyl-5-(4-methoxyphenyl)-5-[(4-methoxyphenyl)thio]pentanoate 
• 1301176-91-9 methyl-2-acetyl-5-(4-methoxyphenyl)-5-(6-methyl-2,4-dioxo-2H-pyran-3-yl)pentanoate 
• 1338781-79-5 methyl 2-acetyl-5-(4-methoxyphenyl)-5-(phenylsulfonyl)pentanoate 
• 1338781-77-3 methyl 2-acetyl-5-(cyclohexylthio)-5-(4-methoxyphenyl)pentanoate 

Relevant academic research and scientific papers

Ring-opening reactions of 2-aryl-3, 4-dihydropyrans with nucleophiles

Ring-opening reactions of 2-aryl-3, 4-dihydropyrans with nucleophiles were reported for the first time. A possible mechanism was also proposed. Finally, this method was used in the synthesis of a novel tetrahydrocarbazole derivative that possesses a biolo

2-Aryl-3,4-dihydropyrans as building blocks for organic synthesis: Ring-opening reactions with nucleophiles

An electrophilic ring-opening reaction of 2-aryl-3,4-dihydropyran with many nucleophiles, such as thiophenols, thiols, benzenesulfinic acid, resorcin, 2-methylfuran, benzamide and allyltrimethylsilane, was developed. In the presence of an appropriate cata

Trapping of active methylene intermediates with alkenes, indoles or thiols: Towards highly selective multicomponent reactions

In this paper, a basic method to access new multicomponent reactions (MCRs) is reported. The mechanism of these MCRs is based on the trapping of methylene intermediates, formed in situ by reaction of formaldehyde with electron-rich carbons, with alkene, thiol or indole derivatives. According to our strategy, a wide range of valuable skeletons has been obtained in a one-pot reaction, thus allowing a minimization of waste, cost and labor. The presented methodology exhibits a broad substrate scope and electron-rich carbons in the α-position of a hydroxy or carbonyl group were found to be particularly efficient. More generally, this work offers new tools for creating molecular complexity and diversity from one of the simplest organic building blocks, formaldehyde.