1219802-61-5 Usage
Uses
Used in Research Applications:
Hexadecanoic--d5 Acid is used as a research compound for various scientific investigations. The incorporation of deuterium atoms into the molecule allows researchers to study the behavior and interactions of this fatty acid in different biological systems without interference from the naturally occurring version. This can be particularly useful in studying metabolic pathways, enzyme activities, and the effects of fatty acids on cellular processes.
Used in Biochemical Analysis:
In the field of biochemistry, Hexadecanoic--d5 Acid can be used as a labeled standard or internal reference in various analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy. The presence of deuterium atoms in the molecule provides a distinct signature, allowing for accurate quantification and identification of the compound in complex biological samples.
Used in Pharmaceutical Research:
Hexadecanoic--d5 Acid can also be employed in the development and testing of new drugs targeting fatty acid metabolism or related pathways. The isotopically labeled compound can be used to study the effects of potential drug candidates on the metabolism and distribution of fatty acids in the body, providing valuable information for the optimization of drug design and the evaluation of their therapeutic potential.
Used in Metabolic Studies:
In the context of metabolic research, Hexadecanoic--d5 Acid can be used to investigate the role of fatty acids in various metabolic processes, such as energy production, lipid synthesis, and cellular signaling. The use of the isotopically labeled compound allows for a more precise understanding of the metabolic pathways and the factors that regulate them, which can contribute to the development of new therapeutic strategies for metabolic disorders.
Used in Nutritional Research:
Hexadecanoic--d5 Acid can be utilized in nutritional studies to explore the effects of dietary fatty acids on health and disease. By incorporating the labeled compound into experimental diets, researchers can investigate the absorption, distribution, and metabolism of fatty acids in the body, as well as their impact on various physiological processes and health outcomes.
Check Digit Verification of cas no
The CAS Registry Mumber 1219802-61-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,1,9,8,0 and 2 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1219802-61:
(9*1)+(8*2)+(7*1)+(6*9)+(5*8)+(4*0)+(3*2)+(2*6)+(1*1)=145
145 % 10 = 5
So 1219802-61-5 is a valid CAS Registry Number.
1219802-61-5Relevant academic research and scientific papers
Mild and Direct Multiple Deuterium-Labeling of Saturated Fatty Acids
Yamada, Tsuyoshi,Park, Kwihwan,Yasukawa, Naoki,Morita, Kosuke,Monguchi, Yasunari,Sawama, Yoshinari,Sajiki, Hironao
supporting information, p. 3277 - 3282 (2016/10/21)
We have established a mild and direct platinum on carbon (Pt/C)-catalyzed multi-deuterium labeling of various saturated fatty acids including bioactive compounds with high deuterium efficiencies in a mixed solvent of isopropyl alcohol and deuterium oxide
Deuterium kinetic isotope effects on the dissociation of a protein-fatty acid complex in the gas phase
Liu, Lan,Michelsen, Klaus,Kitova, Elena N.,Schnier, Paul D.,Brown, Alex,Klassen, John S.
supporting information; scheme or table, p. 5931 - 5937 (2012/05/07)
Deuterium kinetic isotope effects (KIEs) are reported for the first time for the dissociation of a protein-ligand complex in the gas phase. Temperature-dependent rate constants were measured for the loss of neutral ligand from the deprotonated ions of the 1:1 complex of bovine β-lactoglobulin (Lg) and palmitic acid (PA), (Lg + PA)n- → Lgn- + PA, at the 6- and 7- charge states. At 25 °C, partial or complete deuteration of the acyl chain of PA results in a measurable inverse KIE for both charge states. The magnitude of the KIEs is temperature dependent, and Arrhenius analysis of the rate constants reveals that deuteration of PA results in a decrease in activation energy. In contrast, there is no measurable deuterium KIE for the dissociation of the (Lg + PA) complex in aqueous solution at pH 8. Deuterium KIEs were calculated using conventional transition-state theory with an assumption of a late dissociative transition state (TS), in which the ligand is free of the binding pocket. The vibrational frequencies of deuterated and non-deuterated PA in the gas phase and in various solvents (n-hexane, 1-chlorohexane, acetone, and water) were established computationally. The KIEs calculated from the corresponding differences in zero-point energies account qualitatively for the observation of an inverse KIE but do not account for the magnitude of the KIEs nor their temperature dependence. It is proposed that the dissociation of the (Lg + PA) complex in aqueous solution also proceeds through a late TS in which the acyl chain is extensively hydrated such that there is no significant differential change in the vibrational frequencies along the reaction coordinate and, consequently, no significant KIE.
